HEP-1 (Ezrin Peptide) Nasal Spray

Scientific Name: HEP-1 (Ezrin Peptide) Nasal Spray
Clinical Test Expectation: Amplify antiviral immunity. Reduce inflammation and stimulate tissue repair. Treatment HCV, HPV, Herpes, General respiratory viruses. Treat ulcers of the gut, including Inflammatory Bowel Disease (IBD), due to their anti-inflammatory and tissue repair activities. COVID-19 relief and potential COVID-19 cure as per studies shown in product description
MG Strength:  10 mg per vial

Detailed Product Information

Ezrin Peptides amplify antiviral immunity, reduce inflammation and stimulate tissue repair. Ezrin Peptides are safe and no adverse reactions are known. Human Ezrin Peptide One (Gepon) was launched in 2001 in Russia. Ezrin Peptides can effectively treat a wide range of acute and chronic infections caused by viruses, fungi and bacteria. They have been effective in the treatment of viral infections such as HCV, HPV, Herpes, and a wide range of respiratory viruses. Ezrin peptides can also effectively treat ulcers of the gut, including Inflammatory Bowel Disease (IBD), due to their anti-inflammatory and tissue repair activities. RepG3, an ezrin peptide derivative protected by granted patents world-wide, has been found to be an effective treatment for mild-to-moderate COVID in human volunteers in Russia and Germany. 

Result info for HEP-1 (Ezrin Peptide) Nasal Spray

Study Description of HEP-1 (Ezrin Peptide) Nasal Spray

Brief Summary:Currently, SARS-CoV-2 the novel member of the corona virus family, affecting the world leading to COVID-19 disease. It can result life-threatening condition by developing severe acute respiratory distress syndrome (ARDS). Based on previous evidence a group of patients with severe COVID-19 develop a cytokine storm syndrome which leads to hyper-inflammation lung tissue damage. Supportive care is the current management of COVID-19 is and management of ARDS as a main cause of mortality has been remained challenging. Therefore, an urgent effective treatment of COVID-19 regarding hyper-inflammation mechanism is required. Currently, development of novel anti-viral agents and vaccines are the main issues. However, it needs long time, from months to years, until suitable new medications and vaccines have been developed. An immune-modulatory tetra deca peptide (14-mer peptide) named Human Ezrin Peptide 1 (HEP-1) (trade name Gepon) was introduced by the group of Ataullakhanov in Russia. Regarding its proved anti-viral and anti-inflammatory effect, Russian authorities approved Gepon for treatment of ulcerative colitis treatment and Hepatitis -C.

In this regard, it seems that Hep-1 is a very safe immune-modulatory agent which can be effective in the management of COVID-19 infection without any adverse effect for the patient.

Study Design

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Coronavirus Infections

U.S. FDA Resources

Arms and Interventions

Outcome Measures

Primary Outcome Measures :

1. Time to clinical improvement of disease symptoms [ Time Frame: 7 days ]
2. Duration of Hospitalization [ Time Frame: 28 days ]
3. Duration of artificial ventilation [ Time Frame: 28 days ]

Secondary Outcome Measures :

1. CT Severity score [ Time Frame: 28 days ]
2. Range 0-40
3. CBC [ Time Frame: 28 days ]
4. IL-1 [ Time Frame: 28 days ]
5. IL-6 [ Time Frame: 28 days ]
6. TNF [ Time Frame: 28 days ]
7. CRP [ Time Frame: 28 days ]

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Criteria

Inclusion Criteria:

• Patients hospitalized with a positive SARS-CoV-2 PCR test and presenting with one or more clear clinical symptoms of COVID-19 disease
• No contraindication to HEP-1
• Obtained informed consent

Exclusion Criteria:

• Patients who had received any immuno-modulator therapy
• Active or chronic kidney/ liver diseases,
• Oncological diseases
• Other viral infection including HIV and hepatitis.
• Any allergic reaction or sensitivity to HEP-1
• Breast feeding or pregnancy

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04627233

Sponsors and Collaborators

Shahid Beheshti University of Medical Sciences

praxisgemeinschaft für zelltherapie

More Information

Publications:

Bretscher A, Reczek D, Berryman M. Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures. J Cell Sci. 1997 Dec;110 ( Pt 24):3011-8. Review.

Pore D, Gupta N. The ezrin-radixin-moesin family of proteins in the regulation of B-cell immune response. Crit Rev Immunol. 2015;35(1):15-31. Review.

Pore D, Parameswaran N, Matsui K, Stone MB, Saotome I, McClatchey AI, Veatch SL, Gupta N. Ezrin tunes the magnitude of humoral immunity. J Immunol. 2013 Oct 15;191(8):4048-58. doi: 10.4049/jimmunol.1301315. Epub 2013 Sep 16.

Millet JK, Kien F, Cheung CY, Siu YL, Chan WL, Li H, Leung HL, Jaume M, Bruzzone R, Peiris JS, Altmeyer RM, Nal B. Ezrin interacts with the SARS coronavirus Spike protein and restrains infection at the entry stage. PLoS One. 2012;7(11):e49566. doi: 10.1371/journal.pone.0049566. Epub 2012 Nov 21.

Mixing and our recommended dosage

TBA

Additional Information

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