Pal-GHK (Palmitoyl Tripeptide-1)

Introduction

Pal-GHK is a hybrid synthetic molecule made of one-part peptide and one-part fatty acid. The Pal segment of the name refers to palmitoyl, a well-known fatty acid and common component of mammalian cell membranes. The GHK component stands for the peptide sequence glycine-histidine-lysine. This is a small fraction of the much larger elastin protein and a potent stimulant of fibroblasts (cells that synthesize collage, elastin, and other important proteins in the extracellular matrix of skin, bone and other connective tissues). Pal-GHK is often included in research designs with other short peptides .

The GHK component of Pal-GHK tricks fibroblasts into thinking that elastin, a common skin protein, has been damaged. This induces the fibroblasts to grow and multiply so that they can regenerate what they think is the lost elastin in skin. In aging animals, fibroblasts tend to lose activity and become dormant. Studies in animal models indicate that GHK can re-energize fibroblasts and thus help to overcome some of the common effects that aging has on skin

The Pal component of Pal-GHK is simply a vehicle. By attaching this fatty acid to a peptide sequence, it is possible to achieve greater skin and cell penetration in animal models. In other words, the job of Pal is to help GHK get to where it can be of most use to the inside of cells deep within the skin.

Pal-GHK Research show that it has a highly effective result on reducing wrinkles and strengthening skin