Semax (Palmitoyl Tripeptide-1)

Introduction

Semax is an experimental drug that was originally developed back in Russia to prevent and treat circulatory disorders. It has also been identified as a “nootropic” or “cognitive enhancer.” Also known as the Heptapeptide SEMAX (MEHFPGP), it is the analog of ACTH. It has been seen to demonstrate prolonged neuropathic activity. Historically, it has been used in patients experiencing pathologies connected to brain circulation dysfunction. This has also been suggested in literature because of its effects on carboxypeptidase which may increase physical performance and adaptation capacities in exposure due to high intensity and exercises at high doses.

This is a synthetic peptide drug developed based on the molecular structure of adrenocorticotropic hormone (ACTH).Back in Russia, Semax was initially used also to treat strokes and brain damage. This drug has also been reported to have interesting effects on animal models, reducing stress, and enhancing memory performance.

A synthetic form of the adrenocorticotropic hormone is delivered to the body through a Semax nasal spray. It works just like a regular human hormone, which counteracts stress brought by external factors from the environment. Just to give you an idea, an adrenocorticotropic hormone is a kind of hormone which is secreted by the pituitary gland that stimulates the release of cortisol coming from the adrenal gland. It regulates glucose metabolism and maintains blood pressure.

It also primes the brain for action that can reduce behaviors, like procrastination and avoidance. Semax can also induce a controlled state of mental stress, which optimizes brain function.

Semax works through chemical stimulation on the parts of the brain. These parts include:

• limbic reticular complex
• hippocampus
• body’s systems and receptors