SS31 (Elamipretide)

Introduction

SS-31 helps improve mitochondrial function and overall production of energy via ATP synthesis. Research has shown its ability to reduce inflammatory cytokines which cause oxidative stress and inflammatory diseases such as Alzheimer’s, Parkinson’s, heart disease, diabetes, kidney disease, and more.

SS-31 is a synthetic peptide that improves mitochondrial function and is currently undergoing clinical trials for treatments of heart failure, primary mitochondrial myopathy, and other mitochondrial diseases. SS-31 interacts with cardiolipin which is abundant in the inner mitochondrial membrane, but mechanistic details of its pharmacological effects are unknown. Here we apply a chemical cross-linking/mass spectrometry method to provide direct evidence for specific interactions between SS-31 and mitochondrial proteins. The identified SS-31 interactors are functional components in ATP production and 2-oxoglutarate metabolism and signaling, consistent with improved mitochondrial function resultant from SS-31 treatment. These results offer a glimpse of the protein interaction landscape of SS-31 and provide mechanistic insight relevant to SS-31 mitochondrial therapy. More info : https://www.pnas.org/doi/10.1073/pnas.2002250117