Scientific Name: Ghrelin
Clinical Test Expectation:Stimulates appetite, increases food intake and promotes fat storage
MG Strength: 2 mg per vial
Detailed Product Information
Ghrelin /ˈɡrɛlɪn/ (or lenomorelin, INN) is a hormone produced by enteroendocrine cells of the gastrointestinal tract, especially the stomach, and is often called a “hunger hormone” because it increases food intake. Blood levels of ghrelin are highest before meals when hungry, returning to lower levels after mealtimes.
This peptide is a novel gastric hormone recognized in 1999 as a mediator of growth hormone release. Since growth hormone is anabolic, an important function of ghrelin may be to coordinate energy needs with the growth process. Newly discovered biologic roles of ghrelin imply that it may have other important physiological functions as well. This is a review of recent clinically relevant, yet less well-known, physiologic actions of ghrelin.
Summary Background Data:
This peptide has profound orexigenic, adipogenic, and somatotrophic properties, increasing food intake and body weight. Secreted predominantly from the stomach, ghrelin is the natural ligand for the growth hormone secretagogue receptor in the pituitary gland, thus fulfilling criteria of a brain-gut peptide. The brain-gut axis is the effector of anabolism by regulating growth, feeding, and metabolism via vagal afferents mediating ghrelin signaling. However, the wide tissue distribution of ghrelin suggests that it may have other functions as well.
Systematic literature review of all PubMed citations between 1999 and August 2003 focusing on clinically relevant biochemical and physiological characteristics of ghrelin.
This peptide is an important component of an integrated regulatory system of growth and metabolism acting via the vagus nerve, and is implicated in a variety of altered energy states such as obesity, eating disorders, neoplasia, and cachexia. It also enhances immune responses and potentially down-regulates anti-inflammatory molecules. This peptide’s role as a brain-gut peptide emphasizes the significance of afferent vagal fibers as a major pathway to the brain, serving the purpose of maintaining physiologic homeostasis.
The discovery of ghrelin has increased our understanding of feeding regulation, nutritional homeostasis, and metabolic processes. Further characterization of ghrelin’s functions will likely generate new pharmacological approaches to diagnose and treat different disease entities including those related to the over-nutrition of obesity and the catabolic response to surgical trauma.
Anterior pituitary growth hormone (GH) secretion was initially believed to be stimulated by GH-releasing hormone (GHRH) and inhibited by the hypothalamic hormone, somatostatin. The discovery of ghrelin (from “ghre” in the Proto-Indo-European language meaning “grow,” and the suffix “relin” as in “release”), a natural ligand for the growth hormone secretagogue receptor (GHSR), established a novel independent pathway in the regulation of GH release. It was originally found to induce growth hormone release in rats through pituitary GHSR stimulation.1 However, a large body of evidence has shown other physiological functions of ghrelin, distinct from GH release and energy homeostasis. Here we provide an overview of the rapidly expanding field of ghrelin biology, and its potential for developing diagnostic and therapeutic tools.
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